邵春林
复旦大学放射医学研究所， 所长，二级研究员
国家重点研发计划项目首席科学家，长期从事放射生物与肿瘤学、质子重离子效应、FLASH效应等方面的研究工作，主持承担国家重点研发计划、国家自然科学基金重点与面上项目等20多项，发表SCI论文140余篇，是2023、2024年中国高被引学者，获得上海市科技进步一等奖等奖项。兼任中国生物物理学会辐射与环境生物物理专委会会长，中国人体健康科技促进会质子重离子放射治疗专委会副主任委员，中国预防医学会放射卫生专委会副主任委员，中国核学会核应急医学分会副理事长，中国抗癌协会肿瘤放射防护专委会、粒子治疗专委会、放射医学专委会常委等；担任甘肃省重离子医学重点实验室学术委员会主任、吉林省肿瘤放射治疗重点实验室的学术委员会主任、多个国家实验室和国家重点实验室的学术委员会委员；iMED主编，Radiat. Med. Prot.副主编。
一、教育经历
1985.9－1989.7：四川大学，获学士学位
1989.9－1995.6：中国科学院等离子体物理研究所离子束生物工程重点实验室，辐射生物学方向，先后获硕士、博士学位
二、科研与学术工作经历
1995.7－2000.7：中科院等离子体所离子束生物工程重点实验室，历任助理研究员、副研究员，主要从事离子束与生物分子相互作用机制研究
1997.8－1998.3：日本京都大学 生命科学部，访问学者、COE特别研究员，研究方向：DNA辐射损伤
2000.8－2002.7：日本国立放射医学综合研究所，日本科学技术厅STA特别研究员，研究方向：重离子放射效应与信号通路
2002.8－2005.8：英国牛津大学Gray肿瘤研究所 博士后，研究方向：重离子辐射生物效应与机制
2005.8 －现在：复旦大学放射医学研究所，研究员、博士生导师；2007年11月以来历任副所长、党总支书记、所长；主要从事放射医学研究工作
三、主要获得奖项
1. Outstanding Paper Award for Young Scientist, COSPAR（国际空间研究委员会）, 2016，本人为该文的通讯作者。
2. 电离辐射危害防治关键技术研究，上海市科学技术奖一等奖（排名第二），2015。
3. 一种检测电离辐射剂量的生物学方法，2015年度上海市优秀发明金奖（第一完成人）。
四、近期主持及在研项目
2024.12-2028.11
FLASH质子束联合免疫治疗胶质瘤的预后分子标志物研究，科技部“四大慢病”重大专项课题任务
2024.12-2028.11
不同分子分型乳腺癌质子和光子辐射敏感性的擦会议及关键机制研究，科技部“四大慢病”重大专项课题任务
2023.1-2027.12
FLASH光子放疗联合肿瘤免疫治疗的最适物理参量及生物机制研究，国家自然科学基金重点项目
2022.1-2025.12
CD81/SDC1介导的免疫逃逸在胶质瘤辐射抵抗中的作用及其机制研究，国家自然科学基金项目
五、代表性论文
1．Yuchuan Zhou#, Liang Zeng#, Linbo Cai#, Wang Zheng, Xinglong Liu, Yuqi Xiao, Xiaoya Jin, Yang Bai, Mingyao Lai, Hainan Li, Hua Jiang, Songling Hu, Yan Pan*, Jianghong Zhang*, Chunlin Shao*. Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma. Nature Communications. 16(1):1212, 2025.
2．12.Dinghua Liu, Hui Wang, Weitao Yang*, Yang Bai, Zhuoyao Wu, Tianming Cui, Kexin Bian, Jinyan Yi, Chunlin Shao*, and Bingbo Zhang*. One-Dose Bioorthogonal Gadolinium Nanoprobes for Prolonged Radiosensitization of Tumor. Small. 21(15):e2500504, 2025.
3．Jiamei Fu#, Xinglong Liu#, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao*, Yaping Xu*. Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation. Radiation Oncology. 20:20, 2025.
4．Xinglong Liu#, Yimeng Song#, Songling Hu#, Yang Bai, Jianghong Zhang, Guomei Tai*, ChunlinShao*, Yan Pan*. Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway. Int. J. Biol. Sci. 20(12): 4941-4956, 2024.
5．Yuchuan Zhou#, Yuqi Xiao#, Hongxia Liu, Qianping Chen, Lin Zhu, Liang Zeng, Xinglong Liu, Yan Pan, Jianghong Zhang, Jiamei Fu*, Chunlin Shao*. Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression. American Journal of Physiology-Cell Physiology. 326(1): C60-C73, 2024.
6．Liang Zeng#, Wang Zheng#, Xinglong Liu#, Yuchuan Zhou, Xiaoya Jin, Yuqi Xiao, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes. Theranostics, 13(11):3725-3743. 2023.
7．Xinglong Liu†, Liang Zeng†, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao* and Jiamei Fu*. P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin. Journal of Translational Medicine 21:314, 2023.
8．Junmiao Wen#, Wang Zheng#, Liang Zeng, Boyan Wang, Donglai Chen, Xinchen Sun, Yongbing Chen, Xueguan Lu, Chunlin Shao*, Jiayan Chen*, Min Fan*. LTF induces radioresistance by promoting autophagy and forms an AMPK/SP2/NEAT1/miR-214-5p feedback loop in lung squamous cell carcinoma. Int. J. Biol. Sci., 19(5): 1509-1527, 2023.
9．Qianping Chen#, Wang Zheng#, Jian Guan#, Hongxia Liu, Yao Dan, Lin Zhu, Yimeng Song, Yuchuan Zhou1, Xinrui Zhao, Yuhong Zhang, Yang Bai1, Yan Pan1*, Jianghong Zhang*, Chunlin Shao*. SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell Death and Differentiation. 30(1):137-151, 2023.
10．Wang Zheng†, Qianping Chen†, Hongxia Liu, Liang Zeng, Yuchuan Zhou, Xinglong Liu, Yang Bai, Jianghong Zhang*, Yan Pan*, Chunlin Shao*. SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes. Autophagy, 19(3): 839-857, 2023.
11．Xiaolin Shi, Yiwei Yang , Wei Zhang, Jianxin Wang, Dexin Xiao, Huangge Ren, Tingting Wang, Feng Gao, Zhen Liu, Kui Zhou, Peng Li, Zheng Zhou, Peng Zhang, Xuming Shen, Yu Liu, Jianheng Zhao, Zhongmin Wang, Fenju Liu, Chunlin Shao, Dai Wu, and Haowen Zhang. FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy. Proc. Natl. Acad. Sci. USA 119(43): e2208506119, 2022.
12．Yuhong Zhang, Xinglong Liu, Liang Zeng, Xinrui Zhao, Qianping Chen, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment. British J. Cancer. 127(10): 1760-1772, 2022.
13．Xinrui Zhao#, Songling Hu#, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen, Yang Bai1, Jianghong Zhang, Haowen Zhang*, Yan Pan*, Chunlin Shao*. Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation. iScience, 25, 104690, 2022.
14．Qianping Chen#, Wang Zheng#, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang*, Jian Guan*, Chunlin Shao*. LACTB2 Renders Radioresistance by Activating PINK1/Parkin-dependent Mitophagy in Nasopharyngeal Carcinoma Cells. Cancer Letters. 518: 127–139, 2021.
15．Songling Hu#, Lin Zhu#, Yimeng Song#, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang*, Chunlin Shao*. Radiation-induced abscopal reproductive effect is driven by TNF-α/p38 MAPK/Rac1 axis in Sertoli cells. Theranostics. 11(12): 5742-5758, 2021.
16．Lin Zhu#, Songling Hu#, Qian-Ping Chen, Jia-Mei Fu, Hao-Wen Zhang, Jun-Ling Zhang, Yan Pan, Yang Bai, Chun-Lin Shao*. Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors. Int. J. Biol. Sci., 17(4):926-941, 2021.
17．Fei Chen#, Yushuo Zhang#, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang*, Chunlin Shao*. TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation. Cell Death & Disease. 11: 501, 2020.
